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Exam Title : Chemotherapy of Neoplastic Diseases


Number Of Question : 20
Question #1: Which of the following medications is essential for ameliorating the toxicity of pemetrexed?
Folinic acid and vitamin B6
Folic acid and vitamin B12
Vitamin B6 and vitamin B12
Folic acid and dexamethasone
Question #2: Use of tamoxifen for breast cancer can cause all of the following adverse effects, except:
Thromboembolism
Endometrial carcinoma
Carcinoma in contralateral breast
Cataract
Question #3: Mechanism of action of paclitaxel os
Inhibits DNA synthesis
Topoisomerase II inhibitor
Inhibition of tubulin
Stabilisation of tubules
Question #4: All of the following are true about Ifosfamide except:
It is nitrogen mustard
Metabolised by CYP3A4 to form active metabolite
Chloracetaldehyde is active form
Less neurotoxic than cyclophosphamide
Question #5: The most common side effect of cancer chemotherapy is nausea with or without vomiting. The anticancer drugs vary in their ability to cause nausea and vomiting. Which of the following anti-cancer drugs is least likely to cause nausea and vomiting?
Chlorambucil
Cisplatin
Doxorubicin
Daunorubicin